Case Studies

These case studies are presented only as examples and should not be considered as medical advice for any specific patient.

Open Colostomy Reversal

90% Stenosis of Left Circumflex Artery

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56 Year-Old Male Presents With:

  • Colostomy (Image A) following Hartmann's procedure performed for peritonitis secondary to perforated diverticular disease of the sigmoid colon
  • Successful diverticular/perforated colon resection
  • Request for colostomy reversal for restoration of intestinal continuity approximately 12 weeks following initial surgery

Operative Plan:

  • Conventional (open) colostomy reversal
  • To prevent potential leakage, colonic anastomosis was completed using handsewn, single-layer, appositional serosubmucosal technique (Image B), TISSEEL was applied to the anterior (Image C) and posterior anastomotic surface (Image D)

Why TISSEEL [Fibrin Sealant]?

  • Proven efficacy in preventing leakage from colonic anastomosis following the reversal of temporary colostomies1
  • In a single-center, prospective, open-label randomized trial (118 patients: 58 patients standard of care; 60 patients standard of care plus an earlier formulation of TISSEEL), TISSEEL was shown to be effective:
    • For sealing colonic anastomoses
    • For reducing the incidence of anastomotic complications following the reversal of temporary colostomies (p=0.0406)1
  • Available in a pre-filled (frozen) syringe for improved convenience:
    • Just thaw; no mixing or reconstitution required
    • Once thawed, ready to use in a few minutes

Selected Important Risk Information for TISSEEL [Fibrin Sealant]

  • Do not inject TISSEEL directly into the circulatory system or into highly vascularized tissue; thromboembolic events can occur1
  • Do not use in individuals with a known hypersensitivity to aprotinin1
  • Apply TISSEEL as a thin layer by dripping or spraying using cannula or spray set1
  • Do not use for the treatment of severe or brisk arterial or venous bleeding1