Case Studies

These case studies are presented only as examples and should not be considered as medical advice for any specific patient.

Redo CABG/Renal Insufficiency

90% Stenosis of Left Circumflex Artery

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72 year-old patient presents with:

  • History of previous CABG at 63 years-of-age for left coronary artery stenosis
  • Complete occlusion of the posterior descending artery, 90% stenosis of  left circumflex artery
  • Severe aortic valve stenosis
  • Renal insufficiency
  • On clopidogrel 75mg QD

Operative Plan:

  • Redo CABG using saphenous vein grafts via endovascular vein harvesting
  • Aortic valve replacement
  • TISSEEL to control hemostasis in the mediastinal space, epicardial surface, and endovascular vein harvest site

Why TISSEEL [Fibrin Sealant]?

  • Clinically proven efficacy in challenging cardiac reoperations1,2
  • Effective in fully heparinized patients undergoing cardiopulmonary bypass1,2
  • Spray application option for even distribution across broad surfaces
  • Pre-filled syringe eliminates mixing and reconstitution

Selected Important Risk Information for TISSEEL [Fibrin Sealant]

  • Do not inject TISSEEL directly into the circulatory system or into highly vascularized tissue; thromboembolic events can occur1
  • Do not use in individuals with a known hypersensitivity to aprotinin1
  • Apply TISSEEL as a thin layer by dripping or spraying using cannula or spray set1
  • Do not use for the treatment of severe or brisk arterial or venous bleeding1
  • Air or gas embolism has occurred when fibrin sealant was administered using pressurized gas. This can occur if a spray device is used at higher than recommended pressures and in close proximity to the tissue surface1